PTEN Central

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Inactivation Rates

Lesion  Progression

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Biomarker Use



This site contains an image archive of PTEN-null endometrial tissues, along with matched PTEN mutational data, morphometric data from PTEN immunohistochemistry, and patient demographics.  

  1. Background.  PTEN, a tumor suppressor gene which is hormonally regulated in the endometrium.

  2. Inactivation Rates: Compromise of PTEN tumor suppressor gene function is the most common genetic lesion seen in endometrial adenocarcinoma.   Examine rates of lost PTEN expression and mutation/LOH in endometria of a variety of endometria classified by histotologic subtype.

  3. Lesion Progression: Loss of PTEN function occurs at initiation of endometrial tumorigenesis, and can be used to track PTEN-null clones during progression to carcinoma.  See examples of changing PTEN-null clone physical configuration beginning with normal proliferative endometrium and ending with EIN.  Morphometric analysis of PTEN null clone structural features shows trends in changing gland density and size during progression.

  4. Image library: demarcates histological distribution of affected glands in a variety of endometrial diagnostic settings.

  5. Biomarker Use: Uses of PTEN immunohistochemistry as a biomarker for endometrial neoplasia

  6. Methods for PTEN immunohistochemistry. 

  7. Citations used to prepare this section.  You can also do a quick PubMed search for papers about PTEN in the endometrium.


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Copyright 1998-2015 by George L. Mutter, MD.  All Rights Reserved