Citations which Document this Website

    The following peer reviewed citations are some of the primary reports for materials presented in this website.

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EIN Terminology and Diagnosis:

  1. Mutter, G. L. Endometrial hyperplasia without atypia and endometrioid intraepithelial neoplasia (EIN).  in Textbook of Gynaecological Oncology, 2 edn, A. Ayhan, M. Gultekin, & P. Dursun, eds., Gunes, Ankara, Turkey, [in press for 2016].  This is a European  textbook initiated by members of the European Network of Young Gynecologic Oncologists, which contains a thoughtful mix of clinical and diagnostic information. 
     
  2. Mutter GL and Prat J (eds) Pathology of the Female Reproductive Tract. 3rd Edition, New York, New York, Elsevier, 2014.
     
  3. Zaino RJ, et al. Tumours of the uterine corpus: Epithelial tumours and precursors. In: WHO Classification of Tumours of the Female Reproductive Organs. Lyon, France: IARC Press, 2014: 125-134.
     
  4. Parra-Herran CE, Monte NM, Mutter GL. Endometrial intraepithelial neoplasia with secretory differentiation: diagnostic features and underlying mechanisms. Mod Pathol 2013; 26:868-873.
     
  5. Trimble CL, Method M, Leitao M, Lu K, Ioffe O, Hampton M, Higgins R, Zaino R, Mutter GL. Management of Endometrial Precancers. Obstet Gynecol 2012; 120(5):1160-1175.
     
  6. Usubutun A, Mutter GL, Saglam A, Dolgun A, Ozkan EA, Ince T, Akyol A, Bulbul HD, Calay Z, Eren F, Gumurdulu D, Haberal AN, Ilvan S, Karaveli S, Koyuncuoglu M, Muezzinoglu B, Muftuoglu KH, Ozdemir N, Ozen O, Baykara S, Pestereli E, Ulukus EC, Zekioglu O. Reproducibility of endometrial intraepithelial neoplasia diagnosis is good, but influenced by the diagnostic style of pathologists. Mod Pathol 2012; 25(6):877-84.
     
  7. Mutter, G. L. Benign endometrial hyperplasia and endometrial intraepithelial neoplasia (EIN). in Textbook of Gynaecological Oncology, 1 edn, A. Ayhan, M. Gultekin, & P. Dursun, eds., Gunes, Ankara, Turkey, 2010, 44-48.
     
  8. Huang EC, Mutter GL, Crum CP, Nucci MR. Clinical outcome in diagnostically ambiguous foci of 'gland crowding' in the endometrium. Mod Pathol 2010; 23:1486-1491.
     
  9. Lin MC, Lomo L, Baak JPA, Eng C, Ince TA, Crum CP, Mutter GL. Squamous Morules Are Functionally Inert Elements of Premalignant Endometrial Neoplasia. Mod Path 2009; 22:167-174.
     
  10. Carlson JW, Mutter GL. Endometrial Intraepithelial Neoplasia Is Associated With Polyps And Frequently Has Metaplastic Change. Histopathology 2008; 53:325-332.
     
  11. Mutter GL, Zaino RJ, Baak JPA, Bentley RC, Robboy SJ. The Benign Endometrial Hyperplasia Sequence and Endometrial Intraepithelial Neoplasia (EIN). Int J Gynecol Pathol 2007: 26: 103-114.
     
  12. Mutter GL, Duska L, Crum CP. Endometrial Intraepithelial Neoplasia. In: Crum CP, Lee K, editors. Diagnostic Gynecologic and Obstetric Pathology (1st Edition). Philadelphia: Saunders, 2006.
     
  13. Baak JPA, Mutter GL. EIN and WHO94. J Clin Pathol 2005; 58:1-6.
     
  14. Mutter GL, Nogales F, Kurman R, Silverberg S, Tavassoli F, et al. Endometrial Cancer. In: Tavassoli FA, Stratton MR, editors. WHO Classification of Tumors: Pathology and Genetics, Tumors of the Breast and Female Genital Organs. Lyon, France: IARC Press, 2003.
     
  15. Mutter GL. Diagnosis of premalignant endometrial disease. J Clin Pathol 2002; 55:326-31.
     
  16. Mutter GL. Endometrial Intraepithelial Neoplasia: A new standard for precancer diagnosis. Cont Ob Gyn 2001;46:92-8.
     
  17. Mutter,GL and the Endometrial Collaborative Group.  EIN: Will it bring order to chaos?  Gynecologic Oncology,  2000; 76:287-290
     
  18. Mutter GL.  Histopathology of endometrial precancers.  Int.J.Gynecol.Pathol.  2000. 19:301-309.  
     
  19. Mutter GL, Baak JPA, Crum CP, Richart RM, Faquin WC, Boynton KA.  Endometrial precancer diagnosis by histopathology, clonal analysis, and computerized morphometry.  J. Pathology 2000; 190:462-469
     

EIN Clinical Outcome Studies: 

  1. Semere LG, Ko E, Johnson NR, Vitonis AF, Phang LJ, Cramer DW, Mutter GL. Endometrial intraepithelial neoplasia clinical correlates and outcomes: A practice-based experience. Obstet Gynecol 2011; 118 (1): 21-28.
     
  2. Mutter GL, Kauderer J, Baak JPA, Alberts DA. Biopsy histomorphometry predicts uterine myoinvasion by endometrial carcinoma: A Gynecologic Oncology Group Study. Hum Pathol 2008; 39(6):866-74.
     
  3. Hecht JL, Ince TA, Baak JPA, Baker HE, Ogden MW, Mutter GL. Prediction of endometrial carcinoma by subjective EIN diagnosis. Mod Path 2005; 18(3):324-30.
     
  4. Baak JPA, Mutter GL, Robboy S, van Diest PJ, Uyterlinde AM, Orbo A et al. In endometrial hyperplasias, the molecular-genetics and morphometry-based EIN classification more accurately predicts cancer-progression than the WHO94. Cancer 2005; 103(11):103(11): 2304-12.
     
  5. Orbo A, Baak JP, Kleivan I, Lysne S, Prytz PS, Broeckaert MA et al. Computerised morphometrical analysis in endometrial hyperplasia for the prediction of cancer development. A long-term retrospective study from northern Norway. J Clin Pathol 2000; 53(9.:697-703
     
  6. Baak JPA, Nauta J, Wisse-Brekelmans E, Bezemer P. Architectural and nuclear morphometrical features together are more important prognosticators in endometrial hyperplasias than nuclear morphometrical features alone. J Pathol 1988; 154:335-341
     
  7. Baak JP, Orbo A, van Diest PJ, Jiwa M, de Bruin P, Broeckaert M, Snijders W, Boodt PJ, Fons G, Burger C, Verheijen RH, Houben PW, The HS, Kenemans P: Prospective multicenter evaluation of the morphometric D-score for prediction of the outcome of endometrial hyperplasias. Am J Surg Pathol 2001, 25:930-935.
     
  8. Dunton C, Baak J, Palazzo J, van Diest P, McHugh M, Widra E. Use of computerized morphometric analyses of endometrial hyperplasias in the prediction of coexistent cancer. Am J Obstet Gynecol 1996; 174:1518-1521

 

Computerized morphometry of endometrial precancers:

  1. Mutter GL, Kauderer J, Baak JPA, Alberts DA. Biopsy histomorphometry predicts uterine myoinvasion by endometrial carcinoma: A Gynecologic Oncology Group Study. Hum Pathol 2008; 39(6):866-74.
     
  2. Mutter GL, Baak JPA, Crum CP, Richart RM, Faquin WC, Boynton KA.  Endometrial precancer diagnosis by histopathology, clonal analysis, and computerized morphometry.  J. Pathology 2000; 190:462-469.
     
  3. Baak JPA, van Diest PJ. The Female Reproductive Tract. In: Baak JPA, ed. Manual of Quantitative Pathology in Cancer Diagnosis and Prognosis. Heidelberg:Springer-Verlag, 1991:327-356.
     
  4. Baak JPA, Nauta J, Wisse-Brekelmans E, Bezemer P. Architectural and nuclear morphometrical features together are more important prognosticators in endometrial hyperplasias than nuclear morphometrical features alone. J Pathol 1988; 154:335-341
     
  5. Dunton C, Baak J, Palazzo J, van Diest P, McHugh M, Widra E. Use of computerized morphometric analyses of endometrial hyperplasias in the prediction of coexistent cancer. Am J Obstet Gynecol 1996; 174:1518-1521

Endometrial Type Collection and Diagnostic Series:

  1. Mutter GL, Baak JPA, Crum CP, Richart RM, Faquin WC, Boynton KA.  Endometrial precancer diagnosis by histopathology, clonal analysis, and computerized morphometry.  J. Pathology 2000; 190:462-469.
     
  1. Baak JPA, Nauta JJP, Wisse-Brekelmans ECM, Bezemer PD. Architectural and nuclear morphometrical features together are more important prognosticators in endometrial hyperplasia than nuclear features alone. J Pathol 1988: 154; 335-341.

Clonal Analysis and biology of precancerous Endometrial Tissues:

  1. Howitt BE, Monte NM, Elvin J, Mutter GL. Dyssynchronous Secretory Endometrial Glands Often Show Sporadically Acquired Progesterone Nonresponsiveness. Int J Gynecol Pathol 2015; 34:239-244.
     
  2. Mutter GL, Monte NM, Neuberg D, Ferenczy A, Eng C. Emergence, Involution, and Progression to Carcinoma of Mutant Clones in Normal Endometrial Tissues. Cancer Res 2014;74:2796-802.
     
  3. Lin MC, Burkholder KA, Viswanathan AN, Neuberg D, Mutter GL. Involution of latent endometrial precancers by hormonal and non hormonal mechanisms. Cancer 2009; 115(10):2111-2118.
     
  4. Lin MC, Lomo L, Baak JPA, Eng C, Ince TA, Crum CP, Mutter GL. Squamous Morules Are Functionally Inert Elements of Premalignant Endometrial Neoplasia. Mod Path 2009; 22:167-174.
     
  5. Orbo A, Rise CE, Mutter GL. Regression of latent endometrial precancers by progestin infiltrated intrauterine device. Cancer Res 2006;66, 5613-7.
     
  6. Mutter GL. Endometrial carcinogenesis: an integrated molecular, histologic, and functional model of a dualistic disease. In: Giordano A, Bovicelli A, Kurman R, editors. Molecular Pathology of Gynecologic Cancer. Totowa, New Jersey: Humana Press, 2006.
     
  7. Progestins cause involution of PTE-mutant endometrial glands.   Zheng W, Baker HE, Mutter GL. Involution of PTEN-Null Endometrial Glands with Progestin Therapy. Gynecol Oncol 2004; 92:1008-1013.  
    Check here for Supplemental pictures and Table available Here
     
  8. Mutter GL. Clonal analysis of gynecologic tumors. CME Journal of Gynecologic Oncology 2000;5:171-6.
     
  9. Mutter GL, Boynton KA, Faquin WC, Ruiz RE, Jovanovic AS. Allelotype mapping of unstable microsatellites establishes direct lineage continuity between endometrial precancers and cancer. Cancer Res 1996; 56:4483-4486
     
  10. Jovanovic AS, Boynton KA, Mutter GL. Uteri of women with endometrial carcinoma contain a histopathologic spectrum of monoclonal putative precancers, some with microsatellite instability. Cancer Res 1996; 56:1917-1921
     
  11. Mutter GL, Boynton KA. X chromosome inactivation in the normal female genital tract: Implications for identification of neoplasia. Cancer Res 1995; 55:5080-5084.
     
  12. Mutter GL, Boynton KA. PCR bias in amplification of androgen receptor alleles, a trinucleotide repeat marker used in clonality studies. Nucleic Acids Res 1995; 23:1411-1418
     
  13. Mutter GL, Chaponot M, Fletcher J. A PCR assay for non-random X chromosome inactivation identifies monoclonal endometrial cancers and precancers. Am J Pathol 1995; 146:501-508

K-ras, MLH1, Mutations in the Type Collection:

  1. Mutter GL, Wada H, Faquin W, Enomoto T. K-ras mutations appear in the premalignant phase of both microsatellite stable and unstable endometrial carcinogenesis. Mol Pathol 1999; 52:257-262   
     
  2. Esteller M, Catasus L, Matias-Guiu X, Mutter GL, Prat J, Baylin SB, Herman JG. hMLH1 Promoter Hypermethylation Is an Early Event in Human Endometrial Tumorigenesis. Am J Pathol 1999;155:1767-72.

PTEN Tumor Suppressor Gene in Endometrial Precancers: For a live updated search of the literature Click Here

  1. Quick CM, Laury AR, Monte NM, Mutter GL. Utility of PAX2 as a Marker for Diagnosis of Endometrial Intraepithelial Neoplasia. Am J Clin Path 2012; 138:678-684.
     
  2. Monte NM, Webster KA, Neuberg D, Dressler GR, Mutter GL. Joint loss of PAX2 and PTEN expression in endometrial precancers and cancer. Cancer Res 2010; 70:6225-6232.
     
  3. Lin MC, Burkholder KA, Viswanathan AN, Neuberg D, Mutter GL. Involution of latent endometrial precancers by hormonal and non hormonal mechanisms. Cancer 2009; 115(10):2111-2118.
     
  4. Baak JP, van Diermen B, Steinbakk A, Janssen E, Skaland I, Mutter GL et al. Lack of PTEN expression in endometrial intraepithelial neoplasia is correlated with cancer progression. Hum Pathol 2005; 36(5):555-561.
     
  5. Mutter GL, Ince TA, Baak JPA, Kust G, Zhou X, Eng C: Molecular identification of latent precancers in histologically normal endometrium. Cancer Res,6:4311-4314, 2001.
     
  6. Mutter GL: PTEN, a protean tumor suppressor.  Am J Pathol 2001; 158:1895-1898. 
     
  7. Mutter GL, Lin MC, Fitzgerald JT, Kum JB, Baak JPA, Lees J et al. Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers. J Natl Cancer Inst 2000; 92:924-930. 
     
  8. Mutter GL, Lin MC, Fitzgerald JT, Kum JB, Ziebold U, Eng C. Changes in endometrial PTEN expression throughout the human menstrual cycle. J Clin Endocrinol Metab 2000; 85:2334-2338.   

 

Microarray High Throughput Expression Profiling of Endometrial Tissues:For a live updated search of the literature Click Here

  1. Mutter GL, Baak JP, Fitzgerald JT, Gray R, Neuberg D, Kust GA et al. Global expression changes of constitutive and hormonally regulated genes during endometrial neoplastic transformation. Gynecol Oncol 2001; 83(2):177-185.
 

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