Supplemental Data For:

Mutter GL, Lin MC, Fitzgerald JT, Kum JB, Baak JPA, Lees J et al. Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers. J Natl Cancer Inst 2000; 92:924-930.

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Table of Sequenced PTEN Mutations

GM #

Dx

Nucleotide

Codon

Base Change

Amino Acid Change

94-107

Cancer

401

134

DEL T

FS

94-107

Precancer

401

134

DEL T

FS

94-109

Cancer

9

3

del C

FS

94-109

Cancer

12

4

del C

FS

94-109

Precancer

9

3

del C

FS

94-109

Precancer

12

4

del C

FS

94-123

Cancer

324

142

CGG>TGG

R142W

94-123

Cancer

389

130

CGA>CAA

R130Q

94-123

Cancer

334

145

TTT>TGT

F145C

94-123

Cancer

509

170

AGT>ATT

S170I

94-123

Cancer

637

213

CCT>TCT

P213S

94-133

Cancer

388

130

CGA>GGA

R130G

94-154

Cancer

388

130

CGA>TGA

R130X

94-159

Cancer

388

130

CGA>GGA

R130G

94-165

Cancer

800

267

800 DEL A

FS

94-169

Cancer

98

33

ATT>ACT

I33T

94-169

Cancer

111

37

TTT>TTA

I33T

94-169

Precancer

98

33

ATT>ACT

I33T

94-169

Precancer

111

37

TTT>TTA

I33T

94-170

Cancer

208

70

IVS3 + 13 DEL

L70F

94-170

Cancer

437

146

DEL A

FS

94-170

Cancer

433

145

DEL T

FS

94-170

Cancer

594

198

IVS - 28 DL TA

Silent Intronic

94-170

Precancer

594

198

IVS - 28 DL TA

Silent Intronic

94-170

Precancer

437

146

DEL A

FS

94-170

Precancer

433

145

DEL T

FS

94-170

Precancer

208

70

IVS3 + 13 DEL

L70F

94-171

Cancer

492

165

IVS + 12 DEL A

Silent Intronic

94-171

Cancer

795

265

795 DEL A

FS

94-171

Precancer

795

265

795 DEL A

FS

96-4

Cancer

52

18

GAG>TAG

E18X

96-4

Precancer

52

18

GAG>TAG

E18X

96-5

Cancer

632

211

INS G

FS

96-5

Precancer

632

211

INS G

FS

96-6

Cancer

955

319

955-958 DEL ACTT

FS

96-6

Precancer

955

319

955-958 DEL ACTT

FS

96-14

Cancer

955

319

955-958 DEL ACTT

FS

96-14

Precancer

955

319

955-958 DEL ACTT

FS

96-26

Cancer

388

130

CGA>GGA

R130G

96-26

Cancer

511

171

CAG>GAG

Q171E

96-26

Precancer

511

171

CAG>GAG

Q171E

96-26

Precancer

388

130

CGA>GGA

R130G

96-32

Cancer

492

165

IVS 5 - 38 DEL T'S

Intron-Exon boundry

96-32

Precancer

492

165

IVS 5 - 38 DEL T'S

Intron-Exon boundry

96-37

Cancer

32

11

AGA>ATA

R11I

96-37

Cancer

847

283

CCA>TCA

P283S

96-41

Cancer

429

143

DEL A

FS

96-41

Precancer

429

143

DEL A

FS

96-43

Cancer

955

319

955-958 DEL ACTT

FS

96-43

Precancer

955

319

955-958 DEL ACTT

FS

96-51

Cancer

164

55

IVS 2-3 INS TA

exon-intron boundry

96-51

Precancer

164

55

IVS 2-3 INS TA

exon-intron boundry

96-62

Cancer

511

171

IVS 29 A>C

Silent Intronic

96-69

Cancer

611

204

CCA>CAA

P204Q

96-70

Cancer

697

233

GCT>TGA

R233X

96-132

Cancer

278

93

CAT>CGT

H93R

96-150

Cancer

184

62

AAA>TAA

K62X

96-150

Precancer

184

62

AAA>TAA

K62X

96-158

Cancer

196

66

AAG>TAG

L66X

 

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Copyright 1998-2015 by George L. Mutter, MD.  All Rights Reserved