LogoL.GIF (4085 bytes)

Data Repository
at Endometrium.org

An Archive of Images and Data Relating to Endometrial Neoplasia

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Type Collection

PTEN Image Library

EIN Diagnosis Library

Supplemental Data


  1. EIN Fact Sheet:  Concise summary of EIN publications, summary statistics, and diagnostic strategies.  This White Paper was designed for distribution to clinicians and pathologists in practice environments in transition to EIN.

  2. Sylabus of EIN course notes.  These notes cover many aspects of the website in easily printable format.  Revised January, 2008.

  3. The EIN diagnosis library is a series of 50 endometria originally diagnosed in the WHO hyperplasia system, which have been re-diagnosed using EIN criteria.  Formal computerized morphometry (D-Score) and long term clinical followup are available. 

  4. The Endometrial Precancer Type Collection is a group of histologic images presented with a variety of accompanying specialized studies including clonal analysis, K-ras mutation studies, computerized morphometric analysis, and subjective diagnoses (WHO) of a panel of expert pathologists. 

  5. The PTEN Image Library is a collection of PTEN immunohistochemical images along with companion H&E stained slides.  Retrieval by diagnosis, or morphometric parameters is possible.

  6. Course Material for: the ASCP course EIN (Endometrial Intraepithelial Neoplasia) and Ambiguous Premalignant Endometrial Lesions    Archived here at www.endometrium.org  are a Sylabus and a color handout with Unknown Cases. 

Supplemental Data to Published Reports:

Mutter et al, Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers.  JNCI 92:924-931, 2000.

Mutter GL, Ince TA, Baak JPA, Kust G, Zhou X, Eng C. Molecular identification of latent precancers in histologically normal endometrium. Cancer Research  2001; 61 (11):4311-4314.

Mutter GL, Baak JP, Fitzgerald JT, Gray R, Neuberg D, Kust GA et al. Global expression changes of constitutive and hormonally regulated genes during endometrial neoplastic transformation. Gynecol Oncol 2001; 83(2):177-185.

Zheng W, Baker HE, and Mutter GL. Involution of PTEN-Null Endometrial Glands with progestin therapy. Gynecol. Oncol: 2004.

Mutter GL, Zahrieh D, Liu C, Neuberg D, Finkelstein D, Baker HE et al. Comparison of frozen and RNALater solid tissue storage methods for use in RNA expression microarrays. BMC Genomics 2004; 5(1):88.        Data Files available from the Gene Expression Omnibus as accession number GSE1296.


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Copyright 1998-2015 by George L. Mutter, MD.  All Rights Reserved